Mayo Clinic is ranked the #1 hospital overall according to U.S. News & World Report. Mayo Clinic sarcoma experts will work with you to review all of your treatment options and choose the treatment that best suits your needs and goals. The range of treatments offered to people with sarcoma includes: surgery, including innovations designed to preserve function as much as possible, such as rotationplasty and prosthetics, chemotherapy, radiation therapy, including innovative treatments such as intraoperative radiation therapy (IORT), proton therapy and clinical trials.